Loss of Mitochondrial Localization of Human FANCG Causes Defective FANCJ Helicase.
Identifieur interne : 000087 ( Main/Exploration ); précédent : 000086; suivant : 000088Loss of Mitochondrial Localization of Human FANCG Causes Defective FANCJ Helicase.
Auteurs : Jagadeesh Chandra Bose K [Inde] ; Bishwajit Singh Kapoor [Inde] ; Kamal Mandal [Inde] ; Shubhrima Ghosh [Inde] ; Raveendra B. Mokhamatam [Inde] ; Sunil K. Manna [Inde] ; Sudit S. Mukhopadhyay [Inde]Source :
- Molecular and cellular biology [ 1098-5549 ] ; 2020.
Abstract
Fanconi anemia (FA) is a unique DNA damage repair pathway. To date, 22 genes have been identified that are associated with the FA pathway. A defect in any of those genes causes genomic instability, and the patients bearing the mutation become susceptible to cancer. In our earlier work, we identified that Fanconi anemia protein G (FANCG) protects the mitochondria from oxidative stress. In this report, we have identified eight patients having a mutation (C.65G>C), which converts arginine at position 22 to proline (p.Arg22Pro) in the N terminus of FANCG. The mutant protein, hFANCGR22P, is able to repair the DNA and able to retain the monoubiquitination of FANCD2 in the FANCGR22P/FGR22P cell. However, it lost mitochondrial localization and failed to protect mitochondria from oxidative stress. Mitochondrial instability in the FANCGR22P cell causes the transcriptional downregulation of mitochondrial iron-sulfur cluster biogenesis protein frataxin (FXN) and the resulting iron deficiency of FA protein FANCJ, an iron-sulfur-containing helicase involved in DNA repair.
DOI: 10.1128/MCB.00306-20
PubMed: 32989015
PubMed Central: PMC7652403
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Loss of Mitochondrial Localization of Human FANCG Causes Defective FANCJ Helicase.</title><author><name sortKey="K, Jagadeesh Chandra Bose" sort="K, Jagadeesh Chandra Bose" uniqKey="K J" first="Jagadeesh Chandra Bose" last="K">Jagadeesh Chandra Bose K</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Kapoor, Bishwajit Singh" sort="Kapoor, Bishwajit Singh" uniqKey="Kapoor B" first="Bishwajit Singh" last="Kapoor">Bishwajit Singh Kapoor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Mandal, Kamal" sort="Mandal, Kamal" uniqKey="Mandal K" first="Kamal" last="Mandal">Kamal Mandal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Ghosh, Shubhrima" sort="Ghosh, Shubhrima" uniqKey="Ghosh S" first="Shubhrima" last="Ghosh">Shubhrima Ghosh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Mokhamatam, Raveendra B" sort="Mokhamatam, Raveendra B" uniqKey="Mokhamatam R" first="Raveendra B" last="Mokhamatam">Raveendra B. Mokhamatam</name><affiliation wicri:level="1"><nlm:affiliation>Center for DNA Finger Printing and Diagnostics, Hyderabad, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Center for DNA Finger Printing and Diagnostics, Hyderabad</wicri:regionArea><wicri:noRegion>Hyderabad</wicri:noRegion></affiliation></author><author><name sortKey="Manna, Sunil K" sort="Manna, Sunil K" uniqKey="Manna S" first="Sunil K" last="Manna">Sunil K. Manna</name><affiliation wicri:level="1"><nlm:affiliation>Center for DNA Finger Printing and Diagnostics, Hyderabad, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Center for DNA Finger Printing and Diagnostics, Hyderabad</wicri:regionArea><wicri:noRegion>Hyderabad</wicri:noRegion></affiliation></author><author><name sortKey="Mukhopadhyay, Sudit S" sort="Mukhopadhyay, Sudit S" uniqKey="Mukhopadhyay S" first="Sudit S" last="Mukhopadhyay">Sudit S. Mukhopadhyay</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India sudit.mukhopadhyay@bt.nitdgp.ac.in.</nlm:affiliation><country wicri:rule="url">Inde</country><wicri:regionArea>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32989015</idno><idno type="pmid">32989015</idno><idno type="doi">10.1128/MCB.00306-20</idno><idno type="pmc">PMC7652403</idno><idno type="wicri:Area/Main/Corpus">000027</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000027</idno><idno type="wicri:Area/Main/Curation">000027</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000027</idno><idno type="wicri:Area/Main/Exploration">000027</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Loss of Mitochondrial Localization of Human FANCG Causes Defective FANCJ Helicase.</title><author><name sortKey="K, Jagadeesh Chandra Bose" sort="K, Jagadeesh Chandra Bose" uniqKey="K J" first="Jagadeesh Chandra Bose" last="K">Jagadeesh Chandra Bose K</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Kapoor, Bishwajit Singh" sort="Kapoor, Bishwajit Singh" uniqKey="Kapoor B" first="Bishwajit Singh" last="Kapoor">Bishwajit Singh Kapoor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Mandal, Kamal" sort="Mandal, Kamal" uniqKey="Mandal K" first="Kamal" last="Mandal">Kamal Mandal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Ghosh, Shubhrima" sort="Ghosh, Shubhrima" uniqKey="Ghosh S" first="Shubhrima" last="Ghosh">Shubhrima Ghosh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Mokhamatam, Raveendra B" sort="Mokhamatam, Raveendra B" uniqKey="Mokhamatam R" first="Raveendra B" last="Mokhamatam">Raveendra B. Mokhamatam</name><affiliation wicri:level="1"><nlm:affiliation>Center for DNA Finger Printing and Diagnostics, Hyderabad, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Center for DNA Finger Printing and Diagnostics, Hyderabad</wicri:regionArea><wicri:noRegion>Hyderabad</wicri:noRegion></affiliation></author><author><name sortKey="Manna, Sunil K" sort="Manna, Sunil K" uniqKey="Manna S" first="Sunil K" last="Manna">Sunil K. Manna</name><affiliation wicri:level="1"><nlm:affiliation>Center for DNA Finger Printing and Diagnostics, Hyderabad, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Center for DNA Finger Printing and Diagnostics, Hyderabad</wicri:regionArea><wicri:noRegion>Hyderabad</wicri:noRegion></affiliation></author><author><name sortKey="Mukhopadhyay, Sudit S" sort="Mukhopadhyay, Sudit S" uniqKey="Mukhopadhyay S" first="Sudit S" last="Mukhopadhyay">Sudit S. Mukhopadhyay</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India sudit.mukhopadhyay@bt.nitdgp.ac.in.</nlm:affiliation><country wicri:rule="url">Inde</country><wicri:regionArea>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular and cellular biology</title><idno type="eISSN">1098-5549</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fanconi anemia (FA) is a unique DNA damage repair pathway. To date, 22 genes have been identified that are associated with the FA pathway. A defect in any of those genes causes genomic instability, and the patients bearing the mutation become susceptible to cancer. In our earlier work, we identified that Fanconi anemia protein G (FANCG) protects the mitochondria from oxidative stress. In this report, we have identified eight patients having a mutation (C.65G>C), which converts arginine at position 22 to proline (p.Arg22Pro) in the N terminus of FANCG. The mutant protein, hFANCGR22P, is able to repair the DNA and able to retain the monoubiquitination of FANCD2 in the FANCGR22P/FGR22P cell. However, it lost mitochondrial localization and failed to protect mitochondria from oxidative stress. Mitochondrial instability in the FANCGR22P cell causes the transcriptional downregulation of mitochondrial iron-sulfur cluster biogenesis protein frataxin (FXN) and the resulting iron deficiency of FA protein FANCJ, an iron-sulfur-containing helicase involved in DNA repair.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32989015</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Electronic-Print"><Journal><ISSN IssnType="Electronic">1098-5549</ISSN><JournalIssue CitedMedium="Internet"><Volume>40</Volume><Issue>23</Issue><PubDate><Year>2020</Year><Month>11</Month><Day>06</Day></PubDate></JournalIssue><Title>Molecular and cellular biology</Title><ISOAbbreviation>Mol Cell Biol</ISOAbbreviation></Journal><ArticleTitle>Loss of Mitochondrial Localization of Human FANCG Causes Defective FANCJ Helicase.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">e00306-20</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1128/MCB.00306-20</ELocationID><Abstract><AbstractText>Fanconi anemia (FA) is a unique DNA damage repair pathway. To date, 22 genes have been identified that are associated with the FA pathway. A defect in any of those genes causes genomic instability, and the patients bearing the mutation become susceptible to cancer. In our earlier work, we identified that Fanconi anemia protein G (FANCG) protects the mitochondria from oxidative stress. In this report, we have identified eight patients having a mutation (C.65G>C), which converts arginine at position 22 to proline (p.Arg22Pro) in the N terminus of FANCG. The mutant protein, hFANCGR22P, is able to repair the DNA and able to retain the monoubiquitination of FANCD2 in the FANCGR22P/FGR22P cell. However, it lost mitochondrial localization and failed to protect mitochondria from oxidative stress. Mitochondrial instability in the FANCGR22P cell causes the transcriptional downregulation of mitochondrial iron-sulfur cluster biogenesis protein frataxin (FXN) and the resulting iron deficiency of FA protein FANCJ, an iron-sulfur-containing helicase involved in DNA repair.</AbstractText><CopyrightInformation>Copyright © 2020 American Society for Microbiology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>K</LastName><ForeName>Jagadeesh Chandra Bose</ForeName><Initials>JCB</Initials><AffiliationInfo><Affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Kapoor</LastName><ForeName>Bishwajit Singh</ForeName><Initials>BS</Initials><AffiliationInfo><Affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mandal</LastName><ForeName>Kamal</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghosh</LastName><ForeName>Shubhrima</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mokhamatam</LastName><ForeName>Raveendra B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>Center for DNA Finger Printing and Diagnostics, Hyderabad, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manna</LastName><ForeName>Sunil K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Center for DNA Finger Printing and Diagnostics, Hyderabad, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mukhopadhyay</LastName><ForeName>Sudit S</ForeName><Initials>SS</Initials><Identifier Source="ORCID">0000-0001-5888-0598</Identifier><AffiliationInfo><Affiliation>Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India sudit.mukhopadhyay@bt.nitdgp.ac.in.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>11</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Cell Biol</MedlineTA><NlmUniqueID>8109087</NlmUniqueID><ISSNLinking>0270-7306</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">DNA damage</Keyword><Keyword MajorTopicYN="Y">FANCG</Keyword><Keyword MajorTopicYN="Y">FANCJ</Keyword><Keyword MajorTopicYN="Y">ICL cross-link</Keyword><Keyword MajorTopicYN="Y">genomic instability</Keyword><Keyword MajorTopicYN="Y">iron-sulfur cluster</Keyword><Keyword MajorTopicYN="Y">mitochondria</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>09</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2021</Year><Month>05</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>29</Day><Hour>5</Hour><Minute>31</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32989015</ArticleId><ArticleId IdType="pii">MCB.00306-20</ArticleId><ArticleId IdType="doi">10.1128/MCB.00306-20</ArticleId><ArticleId IdType="pmc">PMC7652403</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Blood. 2010 Nov 11;116(19):3780-91</Citation><ArticleIdList><ArticleId IdType="pubmed">20639400</ArticleId></ArticleIdList></Reference><Reference><Citation>Neurosci Lett. 2006 Jan 2;391(3):136-41</Citation><ArticleIdList><ArticleId IdType="pubmed">16165271</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 2017 Jan 2;216(1):83-92</Citation><ArticleIdList><ArticleId IdType="pubmed">28011846</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Genet. 2014 Oct 21;5:372</Citation><ArticleIdList><ArticleId IdType="pubmed">25374583</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Biochem. 2008;77:669-700</Citation><ArticleIdList><ArticleId IdType="pubmed">18366324</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 1999 Jul 15;18(14):3981-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10406803</ArticleId></ArticleIdList></Reference><Reference><Citation>Mitochondrion. 2019 Jan;44:93-102</Citation><ArticleIdList><ArticleId IdType="pubmed">29374544</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2001 Dec 1;98(12):3435-40</Citation><ArticleIdList><ArticleId IdType="pubmed">11719385</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncoscience. 2014 Apr 21;1(4):287-95</Citation><ArticleIdList><ArticleId IdType="pubmed">25594021</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Biophys. 2014;43:257-78</Citation><ArticleIdList><ArticleId IdType="pubmed">24773018</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2010 Oct 21;116(16):2915-20</Citation><ArticleIdList><ArticleId IdType="pubmed">20606166</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Protoc. 2009;4(5):753-66</Citation><ArticleIdList><ArticleId IdType="pubmed">19528951</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14087-91</Citation><ArticleIdList><ArticleId IdType="pubmed">22891333</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2005 Jan 1;105(1):67-73</Citation><ArticleIdList><ArticleId IdType="pubmed">15331448</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2016 Sep 1;126(9):3580-4</Citation><ArticleIdList><ArticleId IdType="pubmed">27500492</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 2006 Aug;26(15):5675-87</Citation><ArticleIdList><ArticleId IdType="pubmed">16847322</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2006 Sep 15;23(6):801-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16973432</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2005 Jan 7;280(1):48-53</Citation><ArticleIdList><ArticleId IdType="pubmed">15501820</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2004 Oct 29;279(44):46035-45</Citation><ArticleIdList><ArticleId IdType="pubmed">15299017</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2008 Jun 12;27(26):3641-52</Citation><ArticleIdList><ArticleId IdType="pubmed">18212739</ArticleId></ArticleIdList></Reference><Reference><Citation>Free Radic Biol Med. 2015 May;82:73-104</Citation><ArticleIdList><ArticleId IdType="pubmed">25640729</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods. 2016 Oct 1;108:118-29</Citation><ArticleIdList><ArticleId IdType="pubmed">27107905</ArticleId></ArticleIdList></Reference><Reference><Citation>Antioxid Redox Signal. 2008 Jun;10(6):997-1030</Citation><ArticleIdList><ArticleId IdType="pubmed">18327971</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Cancer. 2004 Jan 10;108(2):228-31</Citation><ArticleIdList><ArticleId IdType="pubmed">14639607</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2015 Mar 5;57(5):860-872</Citation><ArticleIdList><ArticleId IdType="pubmed">25702873</ArticleId></ArticleIdList></Reference><Reference><Citation>Mutat Res. 2009 Jul 31;668(1-2):133-40</Citation><ArticleIdList><ArticleId IdType="pubmed">19427003</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2014 Apr 11;289(15):10551-65</Citation><ArticleIdList><ArticleId IdType="pubmed">24573678</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 2008 Jul 25;380(5):869-85</Citation><ArticleIdList><ArticleId IdType="pubmed">18572193</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2001 Apr 6;276(14):11317-22</Citation><ArticleIdList><ArticleId IdType="pubmed">11133991</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 2006 Oct 23;175(2):225-35</Citation><ArticleIdList><ArticleId IdType="pubmed">17060495</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 1998 Sep 1;17(17):5026-36</Citation><ArticleIdList><ArticleId IdType="pubmed">9724638</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2009 Jun 26;137(7):1247-58</Citation><ArticleIdList><ArticleId IdType="pubmed">19563757</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Mutat. 2003 Feb;21(2):158-68</Citation><ArticleIdList><ArticleId IdType="pubmed">12552564</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1976 Oct 1;194(4260):23-8</Citation><ArticleIdList><ArticleId IdType="pubmed">959840</ArticleId></ArticleIdList></Reference><Reference><Citation>Free Radic Res. 2012 Feb;46(2):147-53</Citation><ArticleIdList><ArticleId IdType="pubmed">22126415</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Genet. 2020 Jun 15;16(6):e1008740</Citation><ArticleIdList><ArticleId IdType="pubmed">32542039</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Mol Med. 2009 May;9(4):470-82</Citation><ArticleIdList><ArticleId IdType="pubmed">19519404</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Cell Biol. 2014 May;24(5):303-12</Citation><ArticleIdList><ArticleId IdType="pubmed">24314740</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Physiol Cell Physiol. 2011 Apr;300(4):C723-42</Citation><ArticleIdList><ArticleId IdType="pubmed">21209361</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2012 Mar 16;148(6):1145-59</Citation><ArticleIdList><ArticleId IdType="pubmed">22424226</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2005 Jul 15;309(5733):481-4</Citation><ArticleIdList><ArticleId IdType="pubmed">16020738</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2002 Feb;18(2):298-305</Citation><ArticleIdList><ArticleId IdType="pubmed">11847077</ArticleId></ArticleIdList></Reference><Reference><Citation>Acta Biochim Pol. 2014;61(4):671-8</Citation><ArticleIdList><ArticleId IdType="pubmed">25493442</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2017 Apr 05;7:45626</Citation><ArticleIdList><ArticleId IdType="pubmed">28378742</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2010 Aug 20;5(8):e12286</Citation><ArticleIdList><ArticleId IdType="pubmed">20808827</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 2018 Apr 2;217(4):1369-1382</Citation><ArticleIdList><ArticleId IdType="pubmed">29382700</ArticleId></ArticleIdList></Reference><Reference><Citation>Carcinogenesis. 2014 May;35(5):1046-54</Citation><ArticleIdList><ArticleId IdType="pubmed">24442641</ArticleId></ArticleIdList></Reference><Reference><Citation>Dis Model Mech. 2012 Mar;5(2):155-64</Citation><ArticleIdList><ArticleId IdType="pubmed">22382365</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochim Biophys Acta. 2012 Sep;1823(9):1491-508</Citation><ArticleIdList><ArticleId IdType="pubmed">22609301</ArticleId></ArticleIdList></Reference><Reference><Citation>Mutat Res. 2010 Jul 7;689(1-2):12-20</Citation><ArticleIdList><ArticleId IdType="pubmed">20450923</ArticleId></ArticleIdList></Reference><Reference><Citation>Mutagenesis. 2006 Nov;21(6):361-7</Citation><ArticleIdList><ArticleId IdType="pubmed">17065161</ArticleId></ArticleIdList></Reference><Reference><Citation>Genetics. 1976 Aug;83(4):645-53</Citation><ArticleIdList><ArticleId IdType="pubmed">786779</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10775-82</Citation><ArticleIdList><ArticleId IdType="pubmed">20495089</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="K, Jagadeesh Chandra Bose" sort="K, Jagadeesh Chandra Bose" uniqKey="K J" first="Jagadeesh Chandra Bose" last="K">Jagadeesh Chandra Bose K</name></noRegion><name sortKey="Ghosh, Shubhrima" sort="Ghosh, Shubhrima" uniqKey="Ghosh S" first="Shubhrima" last="Ghosh">Shubhrima Ghosh</name><name sortKey="Kapoor, Bishwajit Singh" sort="Kapoor, Bishwajit Singh" uniqKey="Kapoor B" first="Bishwajit Singh" last="Kapoor">Bishwajit Singh Kapoor</name><name sortKey="Mandal, Kamal" sort="Mandal, Kamal" uniqKey="Mandal K" first="Kamal" last="Mandal">Kamal Mandal</name><name sortKey="Manna, Sunil K" sort="Manna, Sunil K" uniqKey="Manna S" first="Sunil K" last="Manna">Sunil K. Manna</name><name sortKey="Mokhamatam, Raveendra B" sort="Mokhamatam, Raveendra B" uniqKey="Mokhamatam R" first="Raveendra B" last="Mokhamatam">Raveendra B. Mokhamatam</name><name sortKey="Mukhopadhyay, Sudit S" sort="Mukhopadhyay, Sudit S" uniqKey="Mukhopadhyay S" first="Sudit S" last="Mukhopadhyay">Sudit S. Mukhopadhyay</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/IronSulferCluV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000087 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000087 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= IronSulferCluV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32989015
|texte= Loss of Mitochondrial Localization of Human FANCG Causes Defective FANCJ Helicase.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32989015" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a IronSulferCluV1
| This area was generated with Dilib version V0.6.38. |  |